The Cardiovascular Biophysics Laboratory employs both interdisciplinary and multidisciplinary methods encompassing selected aspects of engineering, physics, physiology, clinical cardiology, and the biomedical sciences. The overall goal is to solve basic and applied problems in physiology and medicine that have translational potential using causal, rather correlative methodologies. We thereby seek to advance the frontiers of diagnosis and therapy, as well as to serve as an environment for trainees (undergraduate, graduate, medical students, cardiology fellows and post-docs) to acquire and master concepts, to advance the state of knowledge by model-based prediction of 'new' physiology from first principles, and  participate in physiologic data acquisition and analysis.

Areas of interest include:

• Theoretical (mathematical) biology and physiology.

• Characterization of physical properties of cardiovascular tissue

• Maximal information extraction from in-vivo physiologic signals

• Mathematical modeling of cardiovascular function

• Nonlinear dynamics, thermodynamics and optimization principles of cardiovascular function

• Development of new technology for imaging and physiologic signal processing

Imaging and signal acquisition modalities include multi transducer, micromanometric conductance catheter based cardiac catheterization, ventriculography and angiography, echocardiography, and cardiovascular MRI.