Cardiovascular Biophysics Laboratory

Washington University, School of Medicine

 

Cardiovascular Division
Department of Internal Medicine
Program in Cell Biology and Physiology
Department of Biomedical Engineering
Department of Physics

 
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The Cardiovascular Biophysics Laboratory employs both interdisciplinary and multidisciplinary methods encompassing selected aspects of engineering, physics, physiology, clinical cardiology, and the biomedical sciences. The overall goal is to solve basic and applied problems in physiology and medicine that have translational potential using causal, rather correlative methodologies. We thereby seek to advance the frontiers of diagnosis and therapy, as well as to serve as an environment for trainees (undergraduate, graduate, medical students, cardiology fellows and post-docs) to acquire and master concepts, to advance the state of knowledge by model-based prediction of 'new' physiology from first principles, and  participate in physiologic data acquisition and analysis.

Areas of interest include:

  • Theoretical (mathematical) biology and physiology.

  • Characterization of physical properties of cardiovascular tissue

  • Maximal information extraction from in-vivo physiologic signals

  • Mathematical modeling of cardiovascular function

  • Nonlinear dynamics, thermodynamics and optimization principles of cardiovascular unction

  • Development of new technology for imaging and physiologic signal acquisition and processing

Imaging and signal acquisition modalities include multi transducer, micromanometric conductance catheter based cardiac catheterization, ventriculography and angiography, echocardiography, and cardiovascular MRI.

     

       

    

Our Work in the Popular Press

How do you measure a broken heart? (June 14, 2006)

YouTube interview with Dr.Kovács. (Jan 8, 2008)

Eat less or exercise more? (Jan 10, 2008)

Man of Heart (May 1, 2008)

 

Recent Publication
from
Cardiovascular Biophysics Laboratory

2015

  1. Arvidsson PM, Carlsson M, Kovács SJ., Hakan Arheden H. Atrioventricular plane displacement is NOT the sole mechanism of atrial and ventricular refill" Am J Physiol-Heart and Circulatory Physiology, Perspective 2015(in Press)

  2. Rosaria Nappo, Anna Degiovanni, Virginia Bolzani, Chiara Sartori,Gabriella Di Giovine, Paolo Cerini, Rita Fossaceca, Kovács SJ,Paolo N. Marino. Quantitative Asessment of Atrial Conduit Function: A New Index of Diastolic Dysfunction. Clinical Research in Cardiology 2015 [Full Text]

  3. Kovács SJ. Diastolic Function in Heart Failure. Clinical Medicine Insights: Cardiology. 2015; 9(Suppl 1): 49Š55. Published online 2015 Apr 15. doi: 10.4137/CMC.S18743 [Full Text]

  4. Mossahebi S, Zhu S, Kovács SJ. Fractionating E-wave deceleration time into its stiffness and relaxation components distinguishes pseudonormal from normal filling. Circulation: Cardiovascular Imaging, 2015. [Full Text]

  5. 2014

  6. Zhu S, Morrell T, Apor A, Merkely B, Vago H, Toth A, Ghosh E, Kovács SJ. Diastolic Function Alteration Mechanisms in Physiologic vs. Pathologic Hypertrophy are Elucidated by Model-Based Doppler E-Wave Analysis. J Exercise Science & Fitness,12:2, 88Š95, 2014 . doi:10.1016/j.jesf.2014.10.001 [Full Text]

  7. Shmuylovich L, Chung CS, Kovács SJ. Kinematic Modeling of Left Ventricular Diastolic Function. Chapter 28 in Molecular, Cellular and Tissue Engineering (In Press) The Biomedical Engineering Handbook, Fourth Edition. ISBN-10: 1439825300, CRC Press.

  8. Zhu S, Morrell T, Apor A, Merkeley B, Vago H, Toth A, Ghosh E, Kovács SJ. Diastolic Function Alteration Mechanisms in Physiologic vs. Pathologic Hypertrophy are Elucidated by Model-Based Doppler E-Wave Analysis. J Exercise Science & Fitness, 2014 (In Press).

  9. Ghosh E, Caruthers SD, Kovács SJ. The E-wave generated intraventricular diastolic vortex to L-wave relation: model-based prediction with in-vivo validation. J Appl Physiol, 117: 3, 316-324, 2014.

  10. Mossahebi S, Zhu S, Chen H, Shmuylovich L, Ghosh E, Kovács SJ. Quantification of global diastolic function by kinematic modeling-based analysis of transmitral flow via the Parametrized Diastolic Filling formalism. J Vis Exp 91: e51471, 2014. [Full Text] [Video]

  11. Mossahebi S, Kovács SJ. Diastolic Function in Normal Sinus Rhythm vs. Chronic Atrial Fibrillation: Comparison by Fractionation of E-wave Deceleration Time into Stiffness and Relaxation Components. J AFIB 6(5): 13-19, 2014. [Full Text]

  12. Mossahebi S, Kovács SJ. The isovolumic relaxation to early rapid filling relation: Kinematic model based prediction with in-vivo validation. Physiol Rep, 2(3): e00258, 2014. [Full Text]

  13. Mossahebi S, Kovács SJ. Kinematic Modeling Based Decomposition of Transmitral Flow (Doppler E-wave) Deceleration Time into Stiffness and Relaxation Components. Cardiovascular Engineering & Technology, 5(1): 25-34, 2014. [Abstract]

  14. 2013

  15. Ghosh E, Kovács SJ. The Vortex Formation Time to Diastolic Function Relation: Assessment of Pseudonormalized vs. Normal Filling. Physiological Reports 1(6), 2013. [Full Text]

  16. Mossahebi S, Shmuylovich L, Kovács SJ. The Challenge of Chamber Stiffness Determination in Chronic Atrial Fibrillation vs. Normal Sinus Rhythm: Echocardiographic Prediction with Simultaneous Hemodynamic Validation. J AFIB 6(3): 46-51, 2013. [Full Text]

  17. Ghosh E, Kovács SJ. The quest for load-independent left ventricular chamber properties: Exploring the normalized pressure phase plane. Physiol Rep, 1(3): e00043, 2013. [Full Text]

  18. Hummel SL, Seymour EM, Brook RD, Sheth SS, Ghosh E, Zhu S, Weder AB, Kovács SJ, Kolias TJ. Low-Sodium DASH Diet Improves Diastolic Function and Ventricular-Arterial Coupling in Hypertensive Heart Failure with Preserved Ejection Fraction. Circulation: Heart Failure 2013. [Full Text]

  19. Apor A, Merkely B, Morrell T, Zhu S, Ghosh E, Vá H, Andrássy P, Kovács SJ. Diastolic Function in Olympic Athletes vs. Controls: Stiffness and Relaxation Based Echocardiographic Comparison. Journal of Exercise Science & Fitness. 11(1): 29-34, 2013. [Full Text]

  20. Ghosh E, Kovács SJ. Early Left Ventricular Diastolic Function Quantitation Using Directional Impedances. Annals BME. 41(6): 1269-1278, 2013. [Full Text]

  21. 2012

  22. Töger J, Kanski M, Carlsson M, Kovács SJ, Söderlind G, Arheden H, Heiberg E. Diastolic vortex ring formation in the human left ventricle: quantitative analysis using Lagrangian coherent structures and 4D cardiovascular magnetic resonance velocity mapping. J of Cardiovascular Magnetic Resonance 2012, 14:W30. [Full Text]

  23. Töger J, Kanski M, Carlsson M, Kovács SJ, Söderlind G, Arheden H, Heiberg E. Vortex ring formation in the left ventricle of the heart: Analysis by 4D flow MRI and Lagrangian Coherent Structures. Annals BME. 40(12): 2652-2662, 2012. [Full Text]

  24. Ghosh E, Kovács SJ. Quantitative Assessment of Left Ventricular Diastolic Function Via Longitudinal and Transverse Flow Impedances. Contributed Paper: 34th Annual International IEEE EMBS Conference Proceedings 2012:5595-5598, 2012. [Full Text]

  25. Ghosh E, Kovács SJ. Spatio-temporal attributes of left ventricular pressure decay rate during isovolumic relaxation. Am J Physiol Heart Circ Physiol. 302(5): H1094-1101, 2012. [Full Text]

  26. Mossahebi S, Kovács SJ. Kinematic Modeling-based Left Ventricular Diastatic (Passive) Chamber Stiffness Determination with In-Vivo Validation. Annals BME. 40(5): 987-995, 2012. [Full Text]

  27. 2011

  28. Lloyd CW, Shmuylovich L, Holland MR, Miller JG, Kovács SJ. The diastolic function to cyclic variation of myocardial ultrasonic backscatter relation: the influence of parametrized diastolic filling (PDF) formalism determined chamber properties. Ultrasound Med. Biol. 37(8): 1185-95, 2011. [Full Text]

  29. Mossahebi S, Shmuylovich L, Kovács SJ. The thermodynamics of diastole: kinematic modeling based derivation of the P-V loop to transmitral flow energy relation, with in-vivo validation. Am J Physiol Heart Circ Physiol. 300: H514-H521, 2011. [Full Text]

  30. Kovács SJ. How the (Pediatric) Heart Works When It Contracts: Application of Left Ventricular "Isovolumic Acceleration" as a load-Independent Index of Contractility. J Am Coll Cardiol. 57: 1108-1110, 2011. [Full Text]

  31. 2010

  32. Ghosh E, Shmuylovich L, Kovács SJ. Vortex formation time to left ventricular early, rapid filling relation: model based prediction with echocardiographic validation. J Appl Physiol. 109(6): 1812-1819, 2010. [Full Text]

  33. Zhang W, Shmuylovich L, Kovács SJ. The E-wave delayed relaxation pattern to LV pressure contour relation: model-based prediction with in vivo validation. Ultrasound Med. Biol. 36(3): 497-511, 2010. [Full Text]

  34. Shmuylovich L, Chung CS, Kovács SJ. Last word on point: Counterpoint: Left ventricular volume during diastasis is the physiological in vivo equilibrium volume and is related to diastolic suction. J Appl Physiol. 109(2): 615, 2010. [Full Text]

  35. Shmuylovich L, Chung CS, Kovács SJ. Point: Left ventricular volume during diastasis is the physiological in vivo equilibrium volume and is related to diastolic suction. J Appl Physiol. 109(2): 606-608, 2010. [Full Text]

  36. 2009

  37. Zhang W, Shmuylovich L, Kovács SJ. The Pressure Recovery Ratio: The Invasive Index of LV Relaxation During Filling. Model Model-based Prediction With in in-Vivo Validation. Conf Proc IEEE Eng Med Biol Soc. 2009:3940-3943, 2009. [Full Text]

  38. Shmuylovich L, Kovács SJ. Automated method for calculation of a load-independent index of isovolumic pressure decay from left ventricular pressure data. Conf Proc IEEE Eng Med Biol Soc. 2009:3031-3034, 2009. [Full Text]

  39. Ghosh E, Shmuylovich L, Kovács SJ. Determination of early diastolic LV vortex formation time (T*) via the PDF formalism: a kinematic model of filling. Conf Proc IEEE Eng Med Biol Soc. 2009:2883-2886, 2009. [Full Text]

  40. Zhang W, Kovács SJ. The Age Dependence of Left Ventricular Filling Efficiency. Ultrasound Med Biol. 35: 1076-1085, 2009. [Full Text]

  41. Appleton CP, Kovács SJ. The Role of Left Atrial Function in Diastolic Heart Failure. Circulation: Cardiovascular Imaging. 2009;2:6-9. [Full Text]

  42. 2008

  43. Shmuylovich L, Kovács SJ. Stiffness and relaxation components of the exponential and logistic time constants may be used to derive a load-independent index of isovolumic pressure decay. Am J Physiol Heart Circ Physiol. 295(6): H2551-9, 2008. [Full Text]

  44. Zhang W, Chung CS, Shmuylovich L, Kovács SJ. Last Word on Viewpoint: Is Left Ventricular Volume during Diastasis the Real Equilibrium Volume and What Is Its Relationship to Diastolic Suction? J Appl Physiol, 105: 1019, 2008. [Full Text]

  45. Zhang W, Chung CS, Shmuylovich L, Kovács SJ. Viewpoint: Is Left Ventricular Volume During Diastasis the Real Equilibrium Volume and, What is its Relationship to Diastolic Suction? J Appl Physiol, 105: 1012-1014, 2008. [Full Text]

  46. Kovács SJ, Shmuylovich L, Zhang W. Imaging the motion of the heart with echocardiography: advanced technology provides deeper insights into physiology and diastolic function. MedicaMundi. 52: 31-36, 2008. [Full Text]

  47. Chung CS, Kovács SJ. The physical determinants of left ventricular isovolumic pressure decline: Model-based prediction with in-vivo validation. Am J Physiol Heart Circ Physiol. 2008;294:H1589-H1596. [Full Text]

  48. Riordan MM, Weiss EP, Meyer TE, Ehsani AA, Racette SB, Villareal DT, Fontana L, Holloszy JO, and Kovács SJ. The Effects of Caloric Restriction- and Exercise-Induced Weight Loss on Left Ventricular Diastolic Function. Am J Physiol Heart Circ Physiol. 2008;294:H1174-82. [Abstract] [Full Text]

  49. Riordan MM, Kovács SJ. Elucidation of spatially distinct compensatory mechanisms in diastole: radial compensation for impaired longitudinal filling in left ventricular hypertrophy. J Appl Physiol. 2008;104:513-520. [Full Text]

  50. Zhang W, Kovács SJ. The Diastatic Pressure-Volume Relationship Is Not the Same as the End-Diastolic Pressure-Volume Relationship. Am J Physiol.294: 2750-2760, 2008. [Full Text]

  51. Boskovski M, Shmuylovich L, Kovács SJ. Transmitral Flow Velocity-Contour Variation After Premature Ventricular Contractions: A Novel Test of the Load-Independent Index of Diastolic Filling. Ultrasound Med Biol. 34(12): 1901-1908, 2008. [Abstract]

  52. 2007

  53. Zhang W, Chung CS, Riordan MM, Wu Y, Shmuylovich L, Kovács SJ. The Kinematic Filling Efficiency Index of the Left Ventricle: Contrasting Normal vs. Diabetic Physiology. Ultrasound Med. Biol., 2007;33:842-850. [Full Text]

  54. Shmuylovich L, Kovács SJ. E-wave Deceleration Time May Not Provide an Accurate Determination of Left Ventricular Chamber Stiffness if Left Ventricular Relaxation/Viscoelasticity is Unknown. Am J Physiol Heart Circ Physiol. 292: H2712-H2720, 2007. [Full Text]

  55. Riordan MM, Kovács SJ. Absence of Diastolic Mitral Annular Oscillations is a Marker for Relaxation-related Diastolic Dysfunction. Am J Physiol Heart Circ Physiol. 2007;292:H2952-H2958. [Full Text]

  56. Riordan MM, Kovács SJ. Stiffness and Relaxation-based Quantitation of Radial Left Ventricular Oscillations: Elucidation of Regional Diastolic Function Mechanisms. J Appl Physiol. 2007;102:1862-1870. [Full Text]

  57. Chung CS, Kovács SJ. Pressure Phase-Plane Based Determination of the Onset of Left Ventricular Relaxation. Cardiovasc Eng. 7:162-171, 2007. [Abstract]

  58. 2006

  59. Riordan MM, Kovács SJ. Quantitation of Mitral Annular Oscillations and Longitudinal "Ringing" of the Left Ventricle: A New Window into Longitudinal Diastolic Function. J Appl Physiol 2006 Jan;100:112 - 119.[Full Text]

  60. Chung CS,  Kovács SJ. Consequences of Increasing Heart Rate on Deceleration Time, Velocity Time Integral, and E/A.  American Journal of Cardiology. 2006;97:130-136.        [Full Text]

  61. Meyer TE,  Kovács SJ,  Ehsani AA, Klein S, Holloszy JO, Fontana L. Long-term Caloric Restriction Slows Cardiac Aging in Humans. Journal of the American College of Cardiology, 2006; 47:398-402.[Full Text]

  62. Chung CS, Ajo DM, Kovács SJ. The Isovolumic Pressure to Early Rapid Filling Decay Rate Relation: Model-based Derivation and Validation Via Simultaneous Catheterization-Echocardiography. Journal of Applied Physiology 2006;100:528 - 534. [Full Text]

  63. Shmuylovich L, Kovács SJ. A load-independent index of diastolic filling: model-based derivation with in-vivo validation in control and diastolic dysfunction subjects. Journal of Applied Physiology, 2006;101: 92-101. [Full Text]

  64. Riordan MM, Kovács SJ. Relationship of pulmonary vein flow to left ventricular short-axis epicardial displacement in diastole: model-based prediction with in vivo validation. Am J Physiol Heart Circ Physiol. 2006;291(3):H1210-5. [Full Text]

  65. Wu Y and Kovács SJ. Frequency-based analysis of the early, rapid-filling pressure-flow relation elucidates diastolic efficiency mechanisms. Am J Physiol Heart Circ Physiol. 2006;291: H2942-H2949 [Full Text]

  66. Chung CS, Strunc A, Oliver R, Kovács SJ. Diastolic ventricular-vascular stiffness and relaxation relation: elucidation of coupling via pressure phase plane-derived indexes. Am J Physiol Heart Circ Physiol. 2006;291(5):H2415-23. [Full Text]

  67. Zhang W, Chung CS, Kovács SJ. Derivation and Left Ventricular Pressure Phase Plane Based Validation of a Time Dependent Isometric Crossbridge Attachment Model. Cardiovascular Engineering. 2006;6:132-144 . [Full Text]

  68. Wu Y, Yu Y and Kovács SJ. Contraction-Relaxation Coupling Mechanism Characterization in the Thermodynamic Phase-Plane: Normal vs. Impaired Left Ventricular Ejection Fraction. J App Physiol, 2006;102: 1367-1373. [Full Text]

  69. 2005

  70. Bowman AW, Kovács SJ. Prediction and assessment of the time-varying effective pulmonary vein area via cardiac MRI and Doppler echocardiography. Am J Physiol Heart Circ Physiol. 2005 Jan;288(1):H280-6.[Full Text]

  71. Waters EA, Bowman AW, Kovács SJ. MRI-determined left ventricular "crescent effect": a consequence of the slight deviation of contents of the pericardial sack from the constant-volume state.Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H848-53. [Full Text]

  72. Wu Y, Bowman AW, Kovács SJ. Frequency-Based Analysis of Diastolic Function: The Early Rapid Filling Phase Generates Negative Intraventricular Wave Reflections. Cardiovascular Engineering. 2005 Jan;5(1):1-12.[Abstract]

  73. Riordan MM, Chung CS, Kovács SJ. Diabetes and Diastolic Function: Stiffness and Relaxation from Transmitral Flow. Ultrasound Med. Biol. 2005;31:1589-1596.[Full Text]

  74. 2004

  75. Bowman AW, Kovács SJ. Left atrial conduit volume is generated by deviation from the constant-volume state of the left heart: a combined MRI-echocardiographic study. Am J Physiol Heart Circ Physiol. 2004 Jun;286(6):H2416-24.[Abstract] [Full Text]

  76. Karamanoglu M, Kovács SJ. Thermodynamic phase plane analysis of ventricular contraction and relaxation. Biomed Eng Online. 2004 Mar 5;3(1):6. .[Full Text]

  77. Rogers JH, Caruthers SD, Williams T, Rosa Lin SJ, Meyers D, Lanza GM, Kovács SJ, Lasala JM, Wickline SA. Clinical Utility of Rapid Prescreening Magnetic Resonance Angiography of Peripheral Vascular Disease Prior to Cardiac Catheterization. Journal of Cardiovascular Magnetic Resonance 6(1): 25-31. 2004.[Abstract] [Full Text]

  78. Bowman AW, Frihauf PA, Kovács SJ. Time-varying effective mitral valve area: prediction and validation using cardiac MRI and Doppler echocardiography in normal subjects. Am J Physiol Heart Circ Physiol. 2004 Oct;287(4):H1650-7. [Abstract] [Full Text]

  79. Meyer TE, Karamanoglu M, Ehsani AA, Kovács SJ. Left ventricular chamber stiffness at rest as a determinant of exercise capacity in heart failure subjects with decreased ejection fraction. J Appl Physiol. 2004 Nov;97(5):1667-72. [Full Text]

  80. Chung CS, Karamanoglu M, Kovács SJ. Duration of diastole and its phases as a function of heart rate during supine bicycle exercise. Am J Physiol Heart Circ Physiol. 2004 Nov;287(5):H2003-8. [Full Text]

  81. Bauman L, Chung CS, Karamanoglu M, Kovács SJ. The peak atrioventricular pressure gradient to transmitral flow relation: kinematic model prediction with in vivo validation. J Am Soc Echocardiogr. 2004 Aug;17(8):839-44.[Full Text]