Cardiovascular Biophysics Laboratory

Washington University School of Medicine in St. Louis


Cardiovascular Division
Department of Internal Medicine
Program in Cell Biology and Physiology
Department of Biomedical Engineering
Department of Physics

Washington University School of Medicine
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The Cardiovascular Biophysics Laboratory employs both interdisciplinary and multidisciplinary methods encompassing selected aspects of engineering, physics, physiology, clinical cardiology, and the biomedical sciences. The overall goal is to solve basic and applied problems in physiology and medicine that have translational potential using causal, rather correlative methodologies. We thereby seek to advance the frontiers of diagnosis and therapy, as well as to serve as an environment for trainees (undergraduate, graduate, medical students, cardiology fellows and post-docs) to acquire and master concepts, to advance the state of knowledge by model-based prediction of 'new' physiology from first principles, and  participate in physiologic data acquisition and analysis.

Areas of interest include:

  • Theoretical (mathematical) biology and physiology.

  • Characterization of physical properties of cardiovascular tissue

  • Maximal information extraction from in-vivo physiologic signals

  • Mathematical modeling of cardiovascular function

  • Nonlinear dynamics, thermodynamics and optimization principles of cardiovascular unction

  • Development of new technology for imaging and physiologic signal acquisition and processing

Imaging and signal acquisition modalities include multi transducer, micromanometric conductance catheter based cardiac catheterization, ventriculography and angiography, echocardiography, and cardiovascular MRI.


Recent Publication
Cardiovascular Biophysics Laboratory


Carlsson M, Heiberg E, Ostenfeld E, Steding-Ehrenborg K, Kovács SJ, Flachskampf F, Arheden H. "Functional contribution of circumferential versus longitudinal strain - different concepts suggest conflicting results". Journal of the American College of Cardiology. 2017. Letter to the Editor (In Press).

Maksuti E, Carlsson M, Arheden H, Kovács SJ, Broomé M, and Ugander M. "Hydraulic forces contribute to left ventricular diastolic filling". NATURE/Scientific Reports, online 2 March 2017, doi: 10.1038/srep43505.

Kohli K, Kovács SJ. "The Quest for Load-Independent Left Ventricular Chamber Properties: Exploring the Normalized Pressure-Volume Loop." Physiological Reports 29 March 2017, doi: 10.14814/phy2.13160


Toger J, Kanski M, Arvidsson PM, Carlsson M, Kovács SJ., Borgquist R, Revstedt J, Soderlind G, Arheden H, Heiberg E. "Vortex ring mixing as a measure of diastolic function of the human heart: Phantom validation and initial observations in healthy volunteers and patients with heart failure." Journal of Magnetic Resonance Imaging 2016 Jun 13;43(6):1386-97. Epub 2015 Dec 13.

Arvidsson PM, Kovács SJ.,Toger J, Borgquist R, Heiberg E, Carlsson M, and Arheden H. "Vortex ring behavior provides the epigenetic blueprint for the human heart." NATURE Scientific Reports | 6:22021 | DOI: 10.1038/srep22021. 2016


Our Work in the Popular Press

How do you measure a broken heart? (June 14, 2006)

YouTube interview with Dr.Kovács. (Jan 8, 2008)

Eat less or exercise more? (Jan 10, 2008)

Man of Heart (May 1, 2008)