Cardiovascular Biophysics Laboratory

Washington University School of Medicine in St. Louis

 

Cardiovascular Division
Department of Internal Medicine
Program in Cell Biology and Physiology
Department of Biomedical Engineering
Department of Physics

 
Washington University School of Medicine
Home
Research Areas
People
Demo
Publications
Software
Opportunities
Related Web
Contact Us



Selected examples of data acquisition and imaging methodologies used in our research

 

In order to run demo materials with correct aspect ratio,

please use QuickTime player to view.

QuickTime Player can be downloaded Here. 

Cardiac Catheterization  

Left Ventriculography Animation:

Coronary Arteriography

 

Magnetic Resonance Imaging

(Courtesy of Cardiovascular Magnetic Resonance Laboratories)

 

 

4-Chamber View of Adult's Heart

4-Chamber View of Pediatric Heart and LV Outflow Track View of Pediatric Heart

Short-axis View of Adult's Heart

Contiguous short-axis slices from apex to base

 

 

Constant Volume Physiology of the 4-chambered Heart

 

Motion of Pericardial Sack-Normal Subject

Animation

Nonlinear Dynamics of Ventricular Function as seen in the pressure phase plane (dP/dt vs. P coordinate system)

 

Human

Murine

 

Echocardiography

 

Doppler Transmitral Flow

Velocity of Propagation Vp

Color M-mode of myocardial wall-thinning

 

Normal Heart Function Viewed in Two Axis

 

Imaging of Normal Heart Function
 

Kinematic View of 4-chamber Heart as an Oscillator

 

The key physiologic justification is the reciprocation of atrial-ventricular volumes. When applied to the LV alone in diastole, the kinematic Parametrized Diastolic Filling (PDF) model correclty predicts E-waves contours as belonging to two kinematic regimes: underdamped oscillation and overdamped oscillation. Both model predicted classes are observed clinically. Unique model parameter inversion has been achieved by using E-wave as input and generating chamber stiffness (k), relaxation (c) and load (xo) as output
 

Pathophysiologic Example of Left Ventricle

 

Left Ventricular Hypertrophy