Cardiovascular Biophysics Laboratory

Washington University School of Medicine in St. Louis


Cardiovascular Division
Department of Internal Medicine
Program in Cell Biology and Physiology
Department of Biomedical Engineering
Department of Physics

Washington University School of Medicine
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Selected examples of data acquisition and imaging methodologies used in our research


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Cardiac Catheterization  

Left Ventriculography Animation:

Coronary Arteriography


Magnetic Resonance Imaging

(Courtesy of Cardiovascular Magnetic Resonance Laboratories)



4-Chamber View of Adult's Heart

4-Chamber View of Pediatric Heart and LV Outflow Track View of Pediatric Heart

Short-axis View of Adult's Heart

Contiguous short-axis slices from apex to base



Constant Volume Physiology of the 4-chambered Heart


Motion of Pericardial Sack-Normal Subject


Nonlinear Dynamics of Ventricular Function as seen in the pressure phase plane (dP/dt vs. P coordinate system)







Doppler Transmitral Flow

Velocity of Propagation Vp

Color M-mode of myocardial wall-thinning


Normal Heart Function Viewed in Two Axis


Imaging of Normal Heart Function

Kinematic View of 4-chamber Heart as an Oscillator


The key physiologic justification is the reciprocation of atrial-ventricular volumes. When applied to the LV alone in diastole, the kinematic Parametrized Diastolic Filling (PDF) model correclty predicts E-waves contours as belonging to two kinematic regimes: underdamped oscillation and overdamped oscillation. Both model predicted classes are observed clinically. Unique model parameter inversion has been achieved by using E-wave as input and generating chamber stiffness (k), relaxation (c) and load (xo) as output

Pathophysiologic Example of Left Ventricle


Left Ventricular Hypertrophy